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X-ORIGINAL-URL:https://strobe.colorado.edu/
X-WR-CALNAME:STROBE
X-WR-CALDESC:Building the Microscopes of Tomorrow
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-PUBLISHED-TTL:PT1H
X-MS-OLK-FORCEINSPECTOROPEN:TRUE
BEGIN:VEVENT
CLASS:PUBLIC
DTSTART;TZID=America/Denver:20180402T160000
DTEND;TZID=America/Denver:20180402T160000
DTSTAMP:20200613T061100
UID:MEC-222afbe0d68c61de60374b96f1d86715@strobe.colorado.edu
CREATED:20200613
LAST-MODIFIED:20200617
PRIORITY:5
TRANSP:OPAQUE
SUMMARY:STROBE Seminar: Solving protein structure with laser-controlled electron beams (phase contrast electron microscopy)
DESCRIPTION:Transmission electron microscopy of frozen-hydrated specimens (cryo-EM) enabled atomic-resolution reconstruction of biological macromolecules. However, thin soft matter specimens are almost transparent to the electron beam and are extremely sensitive to radiation damage. This hinders the reconstruction of protein complexes that are either too small or too structurally heterogeneous to be readily discerned in electron micrographs. The visibility of biological macromolecules in cryo-EM images can be improved via electron interferometry, similarly to Zernike phase contrast in optical microscopy. We develop laser-based electron interferometry tools to enable Zernike phase contrast in electron microscopy. Laser coherent control of electron beams holds the promise of expanding the class of protein complexes amenable to cryo-EM reconstruction. Initial demonstration experiments are currently underway.\nHosted by UC Berkeley and broadcast across STROBE nodes.\nEveryone is welcome to attend!\n
URL:https://strobe.colorado.edu/news-events/events/strobe-seminar-solving-protein-structure-with-laser-controlled-electron-beams-phase-contrast-electron-microscopy/
ORGANIZER;CN=University of California Berkeley:MAILTO:
LOCATION:University of California Berkeley
END:VEVENT
END:VCALENDAR