Building the Microscopes of Tomorrow

The STROBE Science & Technology Center brings together imaging science experts from seven universities and partners with national labs, industry and academe to push the boundaries of imaging science capabilities and technologies, while building a diverse workforce that is prepared for 21st century careers in science and technology.

RESEARCH HIGHLIGHTS

STROBE solved a century-old scientific problem: Determining the 3D atomic structure of amorphous solids

Y. Yang, et al., Nature 592, 60–64 (2021).

Amorphous solids such as glass, plastics and rubber are ubiquitous in our daily life and have broad applications ranging from . . .

Charging-driven coarsening and melting of a colloidal nanoparticle monolayer at an ionic-liquid vacuum interface

Bischak, C.G., et al., Soft Matter, 16, 9578-9589 (2020).

Colloidal materials are a platform for studying self-assembly as well as the bottom-up creation of next generation hierarchical materials, and . . .

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STROBE IN THE NEWS

Century-old problem solved with first-ever 3D atomic imaging of an amorphous solid

April 14, 2021|National Science Foundation|

Glass, rubber and plastics all belong to a class of matter called amorphous solids. In . . .

Century-old problem solved with first-ever 3D atomic imaging of an amorphous solid

March 31, 2021|UCLA Newsroom|

UCLA-led study captures the structure of metallic glass. Glass, rubber and plastics all belong to . . .

STROBE AWARDS

Congrats to Kevin Dorney for Receiving a Madame Curie Scholarship at the IMEC Attolab

April 2, 2021|Madame Curie Scholarship|

Kevin Dorney, a former STROBE graduate student at CU Boulder in the Kapteyn and Murnane . . .

Congrats to Iona Binnie for Receiving an NSF Graduate Research Fellowship

March 23, 2021|The NSF Graduate Research Fellowship Program|

The NSF GRFP recognizes and supports outstanding graduate students in NSF-supported STEM disciplines who are . . .

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STROBE IN THE NEWS

Century-old problem solved with first-ever 3D atomic imaging of an amorphous solid

April 14, 2021|National Science Foundation|

Glass, rubber and plastics all belong to a class of matter called amorphous solids. In . . .

Century-old problem solved with first-ever 3D atomic imaging of an amorphous solid

March 31, 2021|UCLA Newsroom|

UCLA-led study captures the structure of metallic glass. Glass, rubber and plastics all belong to . . .

More News

STROBE AWARDS

Congrats to Kevin Dorney for Receiving a Madame Curie Scholarship at the IMEC Attolab

April 2, 2021|Madame Curie Scholarship|

Kevin Dorney, a former STROBE graduate student at CU Boulder in the Kapteyn and Murnane . . .

Congrats to Iona Binnie for Receiving an NSF Graduate Research Fellowship

March 23, 2021|The NSF Graduate Research Fellowship Program|

The NSF GRFP recognizes and supports outstanding graduate students in NSF-supported STEM disciplines who are . . .

More Awards

Ptychographic atomic electron tomography: Towards $Ptychographic atomic electron tomography: Towards three-dimensional imaging of individual light atoms in materials Dillan J. Chang, Dennis S. Kim, Arjun Rana, Xuezeng Tian, Jihan Zhou, Peter Ercius, and Jianwei Miao, Physical Review B, 102, 174101, (2020). DOI: 10.1103/PhysRevB.102.174101 Through numerical simulations, we demonstrate the combination of ptychography and atomic electron tomography as an effective method for low dose imaging of individual low-Z atoms in three dimensions. After generating noisy diffraction patterns with multislice simulations of an aberration-corrected scanning transmission electron microscope through a 5-nm zinc-oxide nanoparticle, we have achieved three-dimensional (3D) imaging of individual zinc and oxygen atoms and their defects by performing tomography on ptychographic projections. The methodology has also been simulated in 2D materials, resolving individual sulfur atoms in vertical WS2/WSe2 van der Waals heterostructure with a low total electron dose where annular-dark-field images fail to resolve. We envision that the development of this method could be instrumental in studying the precise 3D atomic structures of radiation sensitive systems and low-Z atomic structures such as 2D heterostructures, catalysts, functional oxides, and glasses.$

An ultra-compact x-ray free-electron laser J. Ros

Electron-Transparent Thermoelectric Coolers Demons

Liquid-like Interfaces Mediate Structural Phase Tr

Potential of Attosecond Coherent Diffractive Imagi $Potential of Attosecond Coherent Diffractive Imaging A. Rana, J. Zhang, M. Pham, A. Yuan, Y. Lo, H. Jiang, S. J. Osher, J. Miao, Physical Review Letters, 125, 086101, (2020). DOI: 10.1103/physrevlett.125.086101 Attosecond science has been transforming our understanding of electron dynamics in atoms, molecules, and solids. However, to date almost all of the attoscience experiments have been based on spectroscopic measurements because attosecond pulses have intrinsically very broad spectra due to the uncertainty principle and are incompatible with conventional imaging systems. Here we report an important advance towards achieving attosecond coherent diffractive imaging. Using simulated attosecond pulses, we simultaneously reconstruct the spectrum, 17 probes, and 17 spectral images of extended objects from a set of ptychographic diffraction patterns. We further confirm the principle and feasibility of this method by successfully performing a ptychographic coherent diffractive imaging experiment using a light-emitting diode with a broad spectrum. We believe this work clears the way to an unexplored domain of attosecond imaging science, which could have a far-reaching impact across different disciplines.$

Spectral DiffuserCam: lensless snapshot hyperspect

Tilted fluctuation electron microscopy E. Kennedy $Tilted fluctuation electron microscopy E. Kennedy, N. Reynolds, L. Rangel DaCosta, F. Hellman, C. Ophus, M. C. Scott, Applied Physics Letters, 117, 091903, (2020). 10.1063/5.0015532 Fluctuation electron microscopy (FEM) is a scanning nanodiffraction-based method that offers a unique approach to characterizing nanometer-scale medium-range order (MRO) in disordered materials. In addition to determining the degree of MRO, careful analysis of scanning nanodiffraction data can also be used to determine strain in thin film amorphous samples. We applied FEM to characterize the strain and MRO of magnetron sputtered amorphous tantalum (a-Ta) thin films over a range of tilt angles from 0° to 45° in order to measure any deviations between the in-plane and out-of-plane strain and MRO. We validate our approach using electron diffraction simulations of FEM experiments for a-Ta. We measure anisotropic strain in the simulated a-Ta diffraction patterns and find that the experimental a-Ta is isotropically strained within the accuracy of our method. Our approach provides a workflow for acquiring tilted scanning nanodiffraction data, determining the relative strain and ordering as a function of in- and out-of-plane directions, and removing any artifacts induced in FEM data due to strain. We also describe some limitations of the tilted FEM method when applied to thin films with very low strains.$

Attosecond light science and its application for p $Attosecond light science and its application for probing quantum materials X. Shi, C. Liao, Z. Tao, E. Cating-Subramanian, M. Murnane, C. Hernández-García, H. Kapteyn, Journal of Physics B: Atomic, Molecular and Optical Physics, 53, 184008, (2020). 10.1088/1361-6455/aba2fb In this paper, we review the development and application of coherent short wavelength light sources implemented using the high harmonic generation (HHG) process. The physics underlying HHG brought quantum physics into the domain of attosecond time-scales for the first time. The observation and manipulation of electron dynamics on such short time-scales—a capability not conceived—of just a few decades ago—is becoming both more-and-more sophisticated and useful as a route to achieve exquisite control over short wavelength light. New experimental techniques are enabling HHG light sources to provide new insights into fundamental quantum interactions in materials, making it possible for the first time to capture the fastest charge, spin, photon and phonon interactions and to achieve diffraction-limited imaging at short wavelengths.$

Structural basis for STAT2 suppression by flavivir

Fragment-based determination of a proteinase K str $Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER L. S. Richards, C. Millán, J. Miao, M. W. Martynowycz, M. R. Sawaya, T. Gonen, R. J. Borges, I. Usón, J. A. Rodriguez, Acta Crystallographica Section D Structural Biology, 76, 703-712, (2020). 10.1107/s2059798320008049 Structure determination of novel biological macromolecules by X-ray crystallography can be facilitated by the use of small structural fragments, some of only a few residues in length, as effective search models for molecular replacement to overcome the phase problem. Independence from the need for a complete pre-existing model with sequence similarity to the crystallized molecule is the primary appeal of ARCIMBOLDO, a suite of programs which employs this ab initio algorithm for phase determination. Here, the use of ARCIMBOLDO is investigated to overcome the phase problem with the electron cryomicroscopy (cryoEM) method known as microcrystal electron diffraction (MicroED). The results support the use of the ARCIMBOLDO_SHREDDER pipeline to provide phasing solutions for a structure of proteinase K from 1.6 Å resolution data using model fragments derived from the structures of proteins sharing a sequence identity of as low as 20%. ARCIMBOLDO_SHREDDER identified the most accurate polyalanine fragments from a set of distantly related sequence homologues...$

Full characterization of ultrathin 5-nm low- k die

Interpretable molecular models for molybdenum disu

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Building the Microscopes of Tomorrow

RESEARCH HIGHLIGHTS

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STROBE IN THE NEWS

STROBE AWARDS

STROBE IN THE NEWS

STROBE AWARDS

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