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So far Lauren Mason has created 285 blog entries.

Investigating the potential for entangled two-photon excited fluorescence imaging

Setting bounds on the absorption cross-sections of molecular systems. There has been a long-running controversy regarding the “quantum advantage” for multiphoton excitation of molecules with entangled photons and if quantum multiphoton imaging can be realized. Although theoretical proposals have been advanced for decades, no experimental work (with the exception of a publication by Jeff Kimble’s group in the 1990s) appeared in the literature until 2006 when reports from a small number of groups began to emerge of a large quantum enhancement (e.g. up to 10 orders of magnitude) of the two photon excitation rate using entangled pairs compared to classical light. Last year, a paper describing a microscope based on the “entangled two-photon absorption” (E2PA) effect was published in Journal of the American Chemical Society. On the other hand, it has emerged from discussions at scientific meetings that many researchers have failed to replicate the results in these numerous publications, or to find any other evidence for this enhancement. As a result, there is considerable skepticism of the publications making these remarkable claims. Unfortunately, these negative results haven’t been published and therefore a rigorous basis for resolving the controversy hasn’t yet been established. Finally, new experiments at JILA have finally set upper-bounds for the E2PA cross-sections in molecular fluorophores, including those investigated in previous reports. We performed both classical and quantum light excitation in the same optical transmission and fluorescence-based systems with rigorously characterized states of light and measurement sensitivities. We find that E2PA cross-sections are at least four to five orders of magnitude smaller than previously reported. Our results imply that the signals and images reported in previous publications are artifacts. Although we don’t expect this contribution to be the last word on the subject, this work introduces a new level of experimental rigor that will lead towards new designs for quantum microscopes and sensors.

Highlighting the Research Centers within JILA

STROBE is one of the 12 nationwide NSF funded Science and Technology centers. According to Ellen Keister, the STROBE Director of Education: “STROBE research groups have common challenges associated with big data, detectors, as well as pushing the limits of x-ray, electron and visible nano-imaging. STROBE enables research groups to address common challenges, enhance tabletop and national facilities and use new capabilities to address current nano and bio materials challenges.”

While STROBE works on collaboration between investigators within its center, it also encourages collaboration from a younger generation. “STROBE encompasses K-12 outreach, undergraduate education, graduate education programming, essentially focusing on how to build and maintain a top STEM workforce,” Keister comments. “- and do it in a way that is inclusive, and that provides students and trainees with the technical and soft skills and tools they need to be prepared and successful when they go out into the 21st century workforce.”

Exploring X-ray and Laser Science from Imagination to Application

Welcome to the inaugural episode of the President’s Innovation Podcast, a special CU on the Air series. Host Emily Davies speaks with distinguished professor Margaret Murnane, a fellow at JILA, which is a joint institute of the University of Colorado Boulder and the National Institute of Standards and Technology. Dr. Murnane is also a faculty member in the department of physics and electrical and computer engineering at CU Boulder, and has earned numerous prestigious awards for her work in ultrafast laser and x-ray science.

Congrats to Margaret Murnane for Receiving an Honorary Doctorate from the University of Limerick

JILA Fellow Margaret Murnane has been awarded an Honorary Doctorate from the University of Limerick this year – her 6th Honorary Doctorate.

“I hadn’t even known I was being considered for it,” Murnane says of the award. Murnane, a native of Ireland, is excited to add another excuse to return to the country. Growing up in the 1960s and 1970s in Ireland, only 10% of high school graduates at that time had the opportunity to attend university. It wasn’t until the 1980s and 1990s that Ireland had the resources to invest in higher education by expanding their university system, later followed by flourishing science research. Murnane grew up very close to the University of Limerick, which became a university in 1980. She is excited to hopefully be attending the awards ceremony in person in August of 2021. When speaking of her future trip, Murnane stated: “It’ll be great to be able to be with family and friends again.”

Murnane’s group at JILA focuses on ultrafast laser and X-ray science. This year Murnane was also awarded the Franklin Medal in Physics for her work. She shared the award with JILA Fellow Dr. Henry Kapteyn.

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